Our Mission:
Transcriptional regulatory system plays a central role in controlling many biological processes. Numerous diseases result from a breakdown in the regulatory system and a third of human developmental disorders have been attributed to dysfunctional Transcription Factors (TFs). In the past decade, the availability of genome sequences and development of new laboratory techniques have generated information describing the function and organization of regulatory systems on an unprecedented scale. Genomic studies now allow us to examine regulatory systems from a whole-organism perspective; however, many observations made with these data are difficult to store, explore, and visualize.
The continued flood of biological data means that many interesting questions require the application of computational methods to answer them. The combination of computational biology, genomics and information technology enables us to uncover general principles that apply to many different biological systems. Our team joint multidisciplinary researchers apply computational and genomic methods to answer three main questions:
1.How is gene expression regulated?2.Which regulatory elements are involved in the gene regulation process?
3.How to store, calculate, and visualize transcriptional regulatory system, especially in disease states?
